Two pilots were killed and dozens of people injured after a passenger jet collided with an emergency vehicle while landing at LaGuardia Airport late Sunday, forcing a full airport shutdown that is expected to last into Monday afternoon.

The aircraft, identified as Air Canada Express Flight 8646, struck a Port Authority fire truck on the runway at approximately 11:40 p.m. as it arrived from Montreal, according to federal officials and multiple media reports.

Authorities said the pilot and co-pilot were killed in the collision. At least 41 people — including passengers, crew members and first responders — were taken to hospitals, though many have since been released.

The fire truck was responding to a separate incident on the airfield at the time of the crash and had been cleared to cross the runway before the collision, according to early reports and air traffic control audio.

The Federal Aviation Administration issued a ground stop shortly after the incident, citing an “aircraft emergency,” and confirmed the airport would remain closed until at least 2 p.m. Monday to allow for emergency response and investigation.

Emergency crews flooded the runway within minutes, evacuating passengers and securing the damaged aircraft, which sustained severe impact to its front section.

The National Transportation Safety Board has launched an investigation and is dispatching a team to the scene to determine the cause of the crash.

The shutdown has led to widespread travel disruptions, with hundreds of flights canceled or diverted as one of the nation’s busiest airports halted operations.

Officials have not yet released the names of the victims. The incident is expected to renew scrutiny over runway safety and coordination between aircraft and ground vehicles at major U.S. airports.

This is a developing story.